![]() ![]() On rare occasions AML can spread to the eyes, testicles, kidneys, or other organs. Spread to the brain and spinal cord can cause symptoms such as: Less often, leukemia cells can spread to other organs. Spread to the gumsĬertain types of AML may spread to the gums, causing swelling, pain, and bleeding. Rarely, AML will first appear as a chloroma, with no leukemia cells in the bone marrow. A tumor-like collection of AML cells under the skin or other parts of the body is called a chloroma, granulocytic sarcoma, or myeloid sarcoma. If leukemia cells spread to the skin, they can cause lumps or spots that may look like common rashes. Symptoms caused by leukemia spread Spread to the skin The lower ribs usually cover these organs, but when they are enlarged the doctor can feel them. This may be noticed as a fullness or swelling of the belly. Leukemia cells may build up in the liver and spleen, making them larger. Some people with AML have bone pain or joint pain caused by the buildup of leukemia cells in these areas. ![]() They might also have calf swelling from a blood clot called a deep vein thrombosis (DVT) or chest pain and shortness of breath from a blood clot in the lung (called a pulmonary embolism or PE). They might have a nosebleed that won’t stop, or a cut that won’t stop oozing. Patients with a certain type of AML called acute promyelocytic leukemia (APL) might have problems with bleeding and blood clotting. Blood vessels in the eye can be affected as well, leading to blurry vision or even loss of vision. When blood vessels in the lungs are affected, people can have shortness of breath. Some of the symptoms are like those seen with a stroke, and include: Leukostasis is rare, but it is a medical emergency that needs to be treated right away. If the blast count gets very high, these cells can clog up blood vessels and make it hard for normal red blood cells (and oxygen) to get to tissues. The cancer cells in AML (called blasts) are bigger than normal white blood cells and have more trouble going through tiny blood vessels. Symptoms caused by high numbers of leukemia cells Heavy periods (menstrual bleeding) in women.Bruises (or small red or purple spots) on the skin.A shortage of blood platelets (called thrombocytopenia) can lead to: Fever often goes along with the infection.Īlthough people with AML can have high white blood cell counts due to excess numbers of leukemia cells, these cells don’t protect against infection the way normal white blood cells do. People with AML can get infections that don’t seem to go away or may get one infection after another. Infections can occur because of a shortage of normal white blood cells (leukopenia), specifically a shortage of infection-fighting white blood cells called neutrophils (a condition called neutropenia). Symptoms from low white blood cell counts Red blood cells carry oxygen to all of the cells in the body. Symptoms from low red blood cell counts (anemia) ![]() These shortages show up on blood tests, and they can also cause symptoms. As a result, people don't have enough normal red blood cells, white blood cells, and blood platelets. Many signs and symptoms of AML are the result of a shortage of normal blood cells, which happens when the leukemia cells crowd out the normal blood-making cells in the bone marrow. Symptoms caused by low numbers of blood cells More often they are caused by something other than leukemia. People with AML often have several non-specific (general) symptoms. Some are more common with certain subtypes of AML. Acute myeloid leukemia (AML) can cause many different signs and symptoms. ![]()
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